BDBM20119 (2S)-N-(cyanomethyl)-3-phenyl-2-(phenylformamido)propanamide::phenylalanine derivative, 43

SMILES O=C(NCC#N)[C@H](Cc1ccccc1)NC(=O)c1ccccc1

InChI Key InChIKey=WEIUVZVWLANUJJ-UHFFFAOYSA-N

Data  9 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 20119   

TargetPapain(Papaya)
Radboud University Nijmegen

Curated by ChEMBL
LigandPNGBDBM20119((2S)-N-(cyanomethyl)-3-phenyl-2-(phenylformamido)p...)
Affinity DataIC50: 360nMAssay Description:Inhibition of papaya papain using Z-Phe-Arg-pNA substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2016
Entry Details Article
PubMed
TargetPapain(Papaya)
Radboud University Nijmegen

Curated by ChEMBL
LigandPNGBDBM20119((2S)-N-(cyanomethyl)-3-phenyl-2-(phenylformamido)p...)
Affinity DataKi:  62nMAssay Description:Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2008
Entry Details Article
PubMed
TargetCathepsin S(Human)
Rheinische Friedrich-Wilhelms-Universitat Bonn

LigandPNGBDBM20119((2S)-N-(cyanomethyl)-3-phenyl-2-(phenylformamido)p...)
Affinity DataKi:  77nMAssay Description:Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2008
Entry Details Article
PubMed
TargetProcathepsin L(Human)
University of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM20119((2S)-N-(cyanomethyl)-3-phenyl-2-(phenylformamido)p...)
Affinity DataKi:  126nMAssay Description:Inhibition of human cathepsin L using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by substrate addition by fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetProcathepsin L(Bovine)
Rheinische Friedrich-Wilhelms-Universitat Bonn

LigandPNGBDBM20119((2S)-N-(cyanomethyl)-3-phenyl-2-(phenylformamido)p...)
Affinity DataKi:  230nMAssay Description:Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2008
Entry Details Article
PubMed
TargetCathepsin B(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM20119((2S)-N-(cyanomethyl)-3-phenyl-2-(phenylformamido)p...)
Affinity DataKi: >330nMpH: 6.0Assay Description:Inhibition of human liver cathepsin B using Cbz-Arg-Arg-pNA as substrate at pH 6 incubated for 30 mins measured for 20 mins by photometrical analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2017
Entry Details Article
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of S£O Paulo Avenue Trabalhador Sancarlense

Curated by ChEMBL
LigandPNGBDBM20119((2S)-N-(cyanomethyl)-3-phenyl-2-(phenylformamido)p...)
Affinity DataKi:  501nMAssay Description:Covalent inhibition of Trypanosoma cruzi cruzipain using Z-Phe-Arg-7-amidomethylcoumarin as substrate measured after 5 mins by fluorometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of S£O Paulo Avenue Trabalhador Sancarlense

Curated by ChEMBL
LigandPNGBDBM20119((2S)-N-(cyanomethyl)-3-phenyl-2-(phenylformamido)p...)
Affinity DataKi:  501nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of S£O Paulo Avenue Trabalhador Sancarlense

Curated by ChEMBL
LigandPNGBDBM20119((2S)-N-(cyanomethyl)-3-phenyl-2-(phenylformamido)p...)
Affinity DataKi:  501nMAssay Description:Binding affinity to Trypanosoma cruzi Cruzain assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetCathepsin K(Human)
Rheinische Friedrich-Wilhelms-Universitat Bonn

LigandPNGBDBM20119((2S)-N-(cyanomethyl)-3-phenyl-2-(phenylformamido)p...)
Affinity DataKi:  1.50E+3nMAssay Description:Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2008
Entry Details Article
PubMed