BDBM20095 dipeptide-derived nitrile, 16::tert-butyl N-[(1S)-1-[(cyanomethyl)carbamoyl]-2-phenylethyl]carbamate

SMILES CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)NCC#N

InChI Key InChIKey=OYGWLRRBJCSNDB-UHFFFAOYSA-N

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 20095   

TargetPapain(Papaya)
Rheinische Friedrich-Wilhelms-Universitat Bonn

LigandPNGBDBM20095(tert-butyl N-[(1S)-1-[(cyanomethyl)carbamoyl]-2-ph...)
Affinity DataKi:  260nM ΔG°:  -8.98kcal/molepH: 6.5 T: 2°CAssay Description:Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2008
Entry Details Article
PubMed
TargetProcathepsin L(Bovine)
Rheinische Friedrich-Wilhelms-Universitat Bonn

LigandPNGBDBM20095(tert-butyl N-[(1S)-1-[(cyanomethyl)carbamoyl]-2-ph...)
Affinity DataKi:  520nMAssay Description:Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2008
Entry Details Article
PubMed
TargetCathepsin S(Human)
Rheinische Friedrich-Wilhelms-Universitat Bonn

LigandPNGBDBM20095(tert-butyl N-[(1S)-1-[(cyanomethyl)carbamoyl]-2-ph...)
Affinity DataKi:  620nMAssay Description:Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2008
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Rheinische Friedrich-Wilhelms-Universitat Bonn

LigandPNGBDBM20095(tert-butyl N-[(1S)-1-[(cyanomethyl)carbamoyl]-2-ph...)
Affinity DataKi:  700nMAssay Description:Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2008
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Rheinische Friedrich-Wilhelms-Universitat Bonn

LigandPNGBDBM20095(tert-butyl N-[(1S)-1-[(cyanomethyl)carbamoyl]-2-ph...)
Affinity DataKi:  1.26E+3nMAssay Description:Inhibition of human cathepsin L using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by substrate addition by fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM20095(tert-butyl N-[(1S)-1-[(cyanomethyl)carbamoyl]-2-ph...)
Affinity DataKi:  2.51E+3nMAssay Description:Inhibition of recombinant Trypanosoma cruzi cruzain using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCathepsin K(Human)
Rheinische Friedrich-Wilhelms-Universitat Bonn

LigandPNGBDBM20095(tert-butyl N-[(1S)-1-[(cyanomethyl)carbamoyl]-2-ph...)
Affinity DataKi:  4.10E+3nMAssay Description:Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2008
Entry Details Article
PubMed
TargetCathepsin B(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM20095(tert-butyl N-[(1S)-1-[(cyanomethyl)carbamoyl]-2-ph...)
Affinity DataKi:  3.70E+4nMpH: 6.0Assay Description:Inhibition of human liver cathepsin B using Cbz-Arg-Arg-pNA as substrate at pH 6 incubated for 30 mins measured for 20 mins by photometrical analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2017
Entry Details Article
PubMed