BDBM20086 dipeptide-derived nitrile, 6::tert-butyl N-[(1S)-1-[(cyanomethyl)carbamoyl]butyl]carbamate

SMILES CCC[C@H](NC(=O)OC(C)(C)C)C(=O)NCC#N

InChI Key InChIKey=PBHMIOPVNIIFHR-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 20086   

TargetCathepsin B(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM20086(tert-butyl N-[(1S)-1-[(cyanomethyl)carbamoyl]butyl...)
Affinity DataKi: >330nMpH: 6.0Assay Description:Inhibition of human liver cathepsin B using Cbz-Arg-Arg-pNA as substrate at pH 6 incubated for 30 mins measured for 20 mins by photometrical analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2017
Entry Details Article
PubMed
TargetPapain(Papaya)
Rheinische Friedrich-Wilhelms-Universitat Bonn

LigandPNGBDBM20086(tert-butyl N-[(1S)-1-[(cyanomethyl)carbamoyl]butyl...)
Affinity DataKi:  750nM ΔG°:  -8.35kcal/molepH: 6.5 T: 2°CAssay Description:Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2008
Entry Details Article
PubMed
TargetCathepsin S(Human)
Rheinische Friedrich-Wilhelms-Universitat Bonn

LigandPNGBDBM20086(tert-butyl N-[(1S)-1-[(cyanomethyl)carbamoyl]butyl...)
Affinity DataKi:  900nMAssay Description:Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2008
Entry Details Article
PubMed
TargetCathepsin K(Human)
Rheinische Friedrich-Wilhelms-Universitat Bonn

LigandPNGBDBM20086(tert-butyl N-[(1S)-1-[(cyanomethyl)carbamoyl]butyl...)
Affinity DataKi:  1.10E+3nMAssay Description:Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2008
Entry Details Article
PubMed
TargetProcathepsin L(Bovine)
Rheinische Friedrich-Wilhelms-Universitat Bonn

LigandPNGBDBM20086(tert-butyl N-[(1S)-1-[(cyanomethyl)carbamoyl]butyl...)
Affinity DataKi:  2.20E+4nMAssay Description:Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2008
Entry Details Article
PubMed