BDBM200638 US9227977, Compound (I)

SMILES COCCOCCOCC#Cc1cccc2nc(Cn3nc(-c4cc(O)cc(F)c4)c4c(N)ncnc34)n(Cc3ccccc3C(F)(F)F)c(=O)c12

InChI Key InChIKey=JTACVHJPXOKMTI-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 200638   

LigandPNGBDBM200638(US9227977, Compound (I))
Affinity DataIC50: 1.39E+4nMAssay Description:The PI3K enzymes catalyse the phosphorylation of phosphatidylinositol 4,5-biphosphate (PIP2) to phosphatidylinositol 3,4,5-triphosphate (PIP3) in the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2016
Entry Details
Go to US Patent

LigandPNGBDBM200638(US9227977, Compound (I))
Affinity DataIC50: 4.89E+3nMAssay Description:The PI3K enzymes catalyse the phosphorylation of phosphatidylinositol 4,5-biphosphate (PIP2) to phosphatidylinositol 3,4,5-triphosphate (PIP3) in the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2016
Entry Details
Go to US Patent

LigandPNGBDBM200638(US9227977, Compound (I))
Affinity DataIC50: 2.5nMAssay Description:The PI3K enzymes catalyse the phosphorylation of phosphatidylinositol 4,5-biphosphate (PIP2) to phosphatidylinositol 3,4,5-triphosphate (PIP3) in the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2016
Entry Details
Go to US Patent

LigandPNGBDBM200638(US9227977, Compound (I))
Affinity DataIC50: 28nMAssay Description:The PI3K enzymes catalyse the phosphorylation of phosphatidylinositol 4,5-biphosphate (PIP2) to phosphatidylinositol 3,4,5-triphosphate (PIP3) in the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2016
Entry Details
Go to US Patent

LigandPNGBDBM200638(US9227977, Compound (I))
Affinity DataIC50: 28nMAssay Description:Inhibition of GST-tagged PI3Kgamma in human U937 cells using PIP2 as substrate preincubated for 10 mins followed by ATP addition measured after 30 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
LigandPNGBDBM200638(US9227977, Compound (I))
Affinity DataIC50: 2.5nMAssay Description:Inhibition of GST-tagged PI3Kdelta in human U937 cells using PIP2 as substrate preincubated for 10 mins followed by ATP addition measured after 30 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed