BDBM200524 Roche-Dataset for PDE10A, Compound 431::US9227970, 26::US9227970, 32

SMILES CCN(CC)c1nc2ccc(NC(=O)c3c(cnn3C)C(=O)N3CCOCC3)cn2n1

InChI Key InChIKey=MZVOUUKBPLZFLB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 200524   

LigandPNGBDBM200524(US9227970, 32 | US9227970, 26 | Roche-Dataset for ...)
Affinity DataIC50: 21.8nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 ul contained 20 mM HEPES pH=7.5/10 mM MgCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2016
Entry Details
Go to US Patent

LigandPNGBDBM200524(US9227970, 32 | US9227970, 26 | Roche-Dataset for ...)
Affinity DataIC50: 2.5nMT: 2°CAssay Description:The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 ul contained 20 mM HEPES pH=7.5/10 mM MgCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2016
Entry Details
Go to US Patent

LigandPNGBDBM200524(US9227970, 32 | US9227970, 26 | Roche-Dataset for ...)
Affinity DataIC50: 22nMAssay Description:Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details Article
PubMed