BDBM198246 US9216999, 54::US9556187, Example 54

SMILES Clc1ccc(CN2CCC(CC2)c2nnn3cnc4[nH]ccc4c23)cc1

InChI Key InChIKey=LMRQNYMDDPQEAJ-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 198246   

TargetTyrosine-protein kinase JAK2(Human)
Nissan Chemical Industries

US Patent
LigandPNGBDBM198246(US9216999, 54 | US9556187, Example 54)
Affinity DataIC50: 15nMpH: 7.5Assay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2016
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Nissan Chemical Industries

US Patent
LigandPNGBDBM198246(US9216999, 54 | US9556187, Example 54)
Affinity DataIC50: 71nMpH: 7.5Assay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2016
Entry Details
Go to US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nissan Chemical Industries

US Patent
LigandPNGBDBM198246(US9216999, 54 | US9556187, Example 54)
Affinity DataIC50: 210nMpH: 7.5Assay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2016
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Nissan Chemical Industries

US Patent
LigandPNGBDBM198246(US9216999, 54 | US9556187, Example 54)
Affinity DataIC50: 1.20nMpH: 7.5Assay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2016
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Nissan Chemical Industries

US Patent
LigandPNGBDBM198246(US9216999, 54 | US9556187, Example 54)
Affinity DataIC50: 1.20nMT: 2°CAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Nissan Chemical Industries

US Patent
LigandPNGBDBM198246(US9216999, 54 | US9556187, Example 54)
Affinity DataIC50: 15nMT: 2°CAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Nissan Chemical Industries

US Patent
LigandPNGBDBM198246(US9216999, 54 | US9556187, Example 54)
Affinity DataIC50: 71nMT: 2°CAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
Go to US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nissan Chemical Industries

US Patent
LigandPNGBDBM198246(US9216999, 54 | US9556187, Example 54)
Affinity DataIC50: 210nMT: 2°CAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Nissan Chemical Industries

US Patent
LigandPNGBDBM198246(US9216999, 54 | US9556187, Example 54)
Affinity DataIC50: 3nMT: 2°CAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Nissan Chemical Industries

US Patent
LigandPNGBDBM198246(US9216999, 54 | US9556187, Example 54)
Affinity DataIC50: 32nMT: 2°CAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Nissan Chemical Industries

US Patent
LigandPNGBDBM198246(US9216999, 54 | US9556187, Example 54)
Affinity DataIC50: 470nMT: 2°CAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
Go to US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Nissan Chemical Industries

US Patent
LigandPNGBDBM198246(US9216999, 54 | US9556187, Example 54)
Affinity DataIC50: 320nMT: 2°CAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
Go to US Patent