BDBM197217 US9090621, 88B::US9572811, Example 43A

SMILES COCCNC(C)(C)C=C(C#N)C(=O)N1CCC[C@H]1Cn1nc(-c2ccc(Oc3ccccc3)cc2F)c2c(N)ncnc12

InChI Key InChIKey=ZUCVBIOQSDKVLU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 197217   

TargetTyrosine-protein kinase BTK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM197217(US9090621, 88B | US9572811, Example 43A)
Affinity DataIC50: 29nMT: 2°CAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of Btk kinase activity of a compound of Formula...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2016
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM197217(US9090621, 88B | US9572811, Example 43A)
Affinity DataIC50: 29nMT: 2°CAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of Btk kinase activity of a compound of Formula...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Principia Biopharma

US Patent
LigandPNGBDBM197217(US9090621, 88B | US9572811, Example 43A)
Affinity DataIC50: 1.80nMT: 2°CAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of Btk kinase activity of a compound of Formula...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2019
Entry Details
Go to US Patent