BDBM195869 US9670213, Compound 014 N-(4-(7-oxo-2-(phenylamino)-8(7H)-pteridin-yl)phenyl) acrylamide

SMILES C=CC(=O)Nc1ccc(cc1)-n1c2nc(Nc3ccccc3)ncc2ncc1=O

InChI Key InChIKey=SKEYVRLMSNIOGI-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 195869   

TargetEpidermal growth factor receptor(Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM195869(US9670213, Compound 014 N-(4-(7-oxo-2-(phenylamino...)
Affinity DataIC50: 16nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM195869(US9670213, Compound 014 N-(4-(7-oxo-2-(phenylamino...)
Affinity DataIC50: 26nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM195869(US9670213, Compound 014 N-(4-(7-oxo-2-(phenylamino...)
Affinity DataIC50: 113nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Blk(Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM195869(US9670213, Compound 014 N-(4-(7-oxo-2-(phenylamino...)
Affinity DataIC50: 7.48E+3nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM195869(US9670213, Compound 014 N-(4-(7-oxo-2-(phenylamino...)
Affinity DataIC50: 129nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM195869(US9670213, Compound 014 N-(4-(7-oxo-2-(phenylamino...)
Affinity DataIC50: 165nMAssay Description:Inhibition of human N-terminal GST-tagged FLT3 (564 to 993 residues) expressed in baculovirus expression system using peptide FAM-P2 as substrate inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed