BDBM195858 US9670213, Compound 003 N-(4-(2-(4-morpholino-phenylamino)-7-oxo-8(7H)-pteridin-yl)phenyl)acrylamide

SMILES C=CC(=O)Nc1ccc(cc1)-n1c2nc(Nc3ccc(cc3)N3CCOCC3)ncc2ncc1=O

InChI Key InChIKey=CHFSRPYBDAIBQR-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 195858   

TargetEpidermal growth factor receptor [T790M](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM195858(US9670213, Compound 003 N-(4-(2-(4-morpholino-phen...)
Affinity DataIC50: 8.70E+3nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM195858(US9670213, Compound 003 N-(4-(2-(4-morpholino-phen...)
Affinity DataIC50: 8.01E+3nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM195858(US9670213, Compound 003 N-(4-(2-(4-morpholino-phen...)
Affinity DataIC50: 4.08E+3nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM195858(US9670213, Compound 003 N-(4-(2-(4-morpholino-phen...)
Affinity DataIC50: 3.30E+3nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Blk(Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM195858(US9670213, Compound 003 N-(4-(2-(4-morpholino-phen...)
Affinity DataIC50: 4.17E+3nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM195858(US9670213, Compound 003 N-(4-(2-(4-morpholino-phen...)
Affinity DataIC50: 137nMT: 2°CAssay Description:In vitro enzyme activity assay: wild-type and various mutants (T790M, L858R, L861Q, L858 R/T790M) EGFR, Z′-Lyte Kinase Assay Kit were purchased...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
East China University of Science & Technology

Curated by ChEMBL
LigandPNGBDBM195858(US9670213, Compound 003 N-(4-(2-(4-morpholino-phen...)
Affinity DataIC50: 8.67E+3nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) using Tyr 4 peptide as substrate after 1.5 hrs by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
East China University of Science & Technology

Curated by ChEMBL
LigandPNGBDBM195858(US9670213, Compound 003 N-(4-(2-(4-morpholino-phen...)
Affinity DataIC50: 3.46E+3nMAssay Description:Inhibition of EGFR T790M/L858R double mutant (unknown origin) using Tyr 4 peptide as substrate after 1.5 hrs by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM195858(US9670213, Compound 003 N-(4-(2-(4-morpholino-phen...)
Affinity DataIC50: 5.59E+3nMAssay Description:Inhibition of wild type EGFR (unknown origin) using Tyr 4 peptide as substrate after 1.5 hrs by FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
East China University of Science and Technology

US Patent
LigandPNGBDBM195858(US9670213, Compound 003 N-(4-(2-(4-morpholino-phen...)
Affinity DataIC50: 173nMAssay Description:Inhibition of human N-terminal GST-tagged FLT3 (564 to 993 residues) expressed in baculovirus expression system using peptide FAM-P2 as substrate inc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed