BDBM195536 US10336717, Compound 523::US9212153, 522,Ex. 420

SMILES CN1C(N)=N[C@]2(C1=O)c1cc(ccc1C[C@@]21CC[C@@H](CC1)OC(F)F)C#CC1CC1

InChI Key InChIKey=ALRNPPMJSNVXIC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 195536   

TargetBeta-secretase 1 [1-458](Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM195536(US9212153, 522,Ex. 420 | US10336717, Compound 523)
Affinity DataIC50: 294nMpH: 4.4Assay Description:For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2016
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM195536(US9212153, 522,Ex. 420 | US10336717, Compound 523)
Affinity DataIC50: 2.40nMAssay Description:For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
Go to US Patent