BDBM195529 US10336717, Compound 397::US9212153, 397,Ex. 336

SMILES CN1C(N)=N[C@@]2(C1=O)c1cc(ccc1CC21CCc2ccccc2CC1)-c1cccnc1F

InChI Key InChIKey=DAWZTCXCSMUINX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 195529   

TargetBeta-secretase 1 [1-458](Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM195529(US9212153, 397,Ex. 336 | US10336717, Compound 397)
Affinity DataIC50: 3.40nMpH: 4.4Assay Description:For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2016
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM195529(US9212153, 397,Ex. 336 | US10336717, Compound 397)
Affinity DataIC50: 6.70nMAssay Description:For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM195529(US9212153, 397,Ex. 336 | US10336717, Compound 397)
Affinity DataIC50: 213nMAssay Description:For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM195529(US9212153, 397,Ex. 336 | US10336717, Compound 397)
Affinity DataIC50: 3.40nMAssay Description:For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
Go to US Patent