BDBM1946 (Alkylamino)piperidine BHAP analog 2::2-{2-[2-({2-[(4-{methyl[3-(propan-2-ylamino)pyridin-2-yl]amino}piperidin-1-yl)carbonyl]-1H-indol-6-yl}oxy)ethoxy]ethoxy}ethan-1-ol

SMILES CC(C)Nc1cccnc1N(C)C1CCN(CC1)C(=O)c1cc2ccc(OCCOCCOCCO)cc2[nH]1

InChI Key InChIKey=MAHKICLCUFADJL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 1946   

TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Upjohn

LigandPNGBDBM1946(2-{2-[2-({2-[(4-{methyl[3-(propan-2-ylamino)pyridi...)
Affinity DataIC50: 300nMpH: 8.3 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027,P823L]/[588-1147,P823L](Human immunodeficiency virus type 1)
Upjohn

LigandPNGBDBM1946(2-{2-[2-({2-[(4-{methyl[3-(propan-2-ylamino)pyridi...)
Affinity DataIC50: 410nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,Y768C]/[588-1147,Y768C](Human immunodeficiency virus type 1)
Upjohn

LigandPNGBDBM1946(2-{2-[2-({2-[(4-{methyl[3-(propan-2-ylamino)pyridi...)
Affinity DataIC50: 770nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2004
Entry Details Article
PubMed