BDBM194502 BDBM50392267::US9200020, Table 3 compound 11

SMILES Nc1nc2n(CCN(CCP(O)(O)=O)CCP(O)(O)=O)cnc2c(=O)[nH]1

InChI Key InChIKey=JGCOPSLIOMTBDT-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 194502   

TargetHypoxanthine-guanine phosphoribosyltransferase(Human)
The University of Queensland

US Patent
LigandPNGBDBM194502(US9200020, Table 3 compound 11 | BDBM50392267)
Affinity DataKi:  200nMpH: 7.4Assay Description:The Ki values were determined using a spectrophotometric assay at 25° C., 0.1 M Tris-HCl, 10 mM MgCl2, pH 7.4 (Keough, D. T.; Ng, A. L.; Winzor, D. J...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2016
Entry Details
Go to US Patent

TargetHypoxanthine-guanine phosphoribosyltransferase(Human)
The University of Queensland

US Patent
LigandPNGBDBM194502(US9200020, Table 3 compound 11 | BDBM50392267)
Affinity DataKi:  200nMAssay Description:Inhibition of human HGPRT using Prib-PP as substrate by spectrophotometric assay in presence of guanineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHypoxanthine-guanine-xanthine phosphoribosyltransferase(Plasmodium falciparum)
The University of Queensland

US Patent
LigandPNGBDBM194502(US9200020, Table 3 compound 11 | BDBM50392267)
Affinity DataKi:  300nMpH: 7.4Assay Description:The Ki values were determined using a spectrophotometric assay at 25° C., 0.1 M Tris-HCl, 10 mM MgCl2, pH 7.4 (Keough, D. T.; Ng, A. L.; Winzor, D. J...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2016
Entry Details
Go to US Patent

TargetHypoxanthine phosphoribosyltransferase(Plasmodium vivax)
The University of Queensland

US Patent
LigandPNGBDBM194502(US9200020, Table 3 compound 11 | BDBM50392267)
Affinity DataKi:  900nMpH: 7.4Assay Description:The Ki values were determined using a spectrophotometric assay at 25° C., 0.1 M Tris-HCl, 10 mM MgCl2, pH 7.4 (Keough, D. T.; Ng, A. L.; Winzor, D. J...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2016
Entry Details
Go to US Patent