BDBM1945 (Alkylamino)piperidine BHAP Analog 1::2-N-[1-(1H-indol-2-ylcarbonyl)piperidin-4-yl]-2-N-methyl-3-N-(propan-2-yl)pyridine-2,3-diamine::CHEMBL151565

SMILES CC(C)Nc1cccnc1N(C)C1CCN(CC1)C(=O)c1cc2ccccc2[nH]1

InChI Key InChIKey=MHQJAWRJJKMFDP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 1945   

TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Upjohn

LigandPNGBDBM1945(2-N-[1-(1H-indol-2-ylcarbonyl)piperidin-4-yl]-2-N-...)
Affinity DataIC50: 230nMpH: 8.3 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1027,P823L]/[588-1147,P823L](Human immunodeficiency virus type 1)
Upjohn

LigandPNGBDBM1945(2-N-[1-(1H-indol-2-ylcarbonyl)piperidin-4-yl]-2-N-...)
Affinity DataIC50: 740nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [588-1127,Y768C]/[588-1147,Y768C](Human immunodeficiency virus type 1)
Upjohn

LigandPNGBDBM1945(2-N-[1-(1H-indol-2-ylcarbonyl)piperidin-4-yl]-2-N-...)
Affinity DataIC50: 800nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2004
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM1945(2-N-[1-(1H-indol-2-ylcarbonyl)piperidin-4-yl]-2-N-...)
Affinity DataIC50: 2.00E+3nMAssay Description:In vitro for inhibition of HIV-1 reverse transcriptase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed