BDBM19354 2,4-diaminopyrimidine-based antagonist, 8b::6-ethyl-5-{1-[(4-methanesulfonylphenyl)methyl]-2-phenyl-1H-1,3-benzodiazol-5-yl}pyrimidine-2,4-diamine

SMILES CCc1nc(N)nc(N)c1-c1ccc2n(Cc3ccc(cc3)S(C)(=O)=O)c(nc2c1)-c1ccccc1

InChI Key InChIKey=OJVARHYUTXXZJR-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 19354   

TargetGrowth hormone secretagogue receptor type 1(Human)
Abbott Laboratories

LigandPNGBDBM19354(6-ethyl-5-{1-[(4-methanesulfonylphenyl)methyl]-2-p...)
Affinity DataIC50: 16nM EC50:  249nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2007
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Abbott Laboratories

LigandPNGBDBM19354(6-ethyl-5-{1-[(4-methanesulfonylphenyl)methyl]-2-p...)
Affinity DataIC50: 2.30E+3nMpH: 7.3 T: 2°CAssay Description:DHFR activity was determined by measuring the rate of depletion of NADPH, monitored at 340 nm, with a Beckman DU-7400 spectrophotometer. More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2007
Entry Details Article
PubMed