BDBM19351 2,4-diaminopyrimidine-based antagonist, 4c::6-ethyl-5-(4-{[(4-methanesulfonylphenyl)methyl]amino}phenyl)pyrimidine-2,4-diamine::CHEMBL203280::JMC492568 7b

SMILES CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(cc2)S(C)(=O)=O)cc1

InChI Key InChIKey=IIMYRTZDWODUAY-UHFFFAOYSA-N

Data  5 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 19351   

TargetGrowth hormone secretagogue receptor type 1(Human)
Abbott Laboratories

LigandPNGBDBM19351(6-ethyl-5-(4-{[(4-methanesulfonylphenyl)methyl]ami...)
Affinity DataIC50: 7nM EC50:  19nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2007
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Abbott Laboratories

LigandPNGBDBM19351(6-ethyl-5-(4-{[(4-methanesulfonylphenyl)methyl]ami...)
Affinity DataIC50: 10nMpH: 7.3 T: 2°CAssay Description:DHFR activity was determined by measuring the rate of depletion of NADPH, monitored at 340 nm, with a Beckman DU-7400 spectrophotometer. More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2007
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Abbott Laboratories

LigandPNGBDBM19351(6-ethyl-5-(4-{[(4-methanesulfonylphenyl)methyl]ami...)
Affinity DataIC50: 7.40nM EC50:  12nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2007
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Abbott Laboratories

LigandPNGBDBM19351(6-ethyl-5-(4-{[(4-methanesulfonylphenyl)methyl]ami...)
Affinity DataIC50: 9.70nMAssay Description:Inhibition of human GHS receptor by binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Abbott Laboratories

LigandPNGBDBM19351(6-ethyl-5-(4-{[(4-methanesulfonylphenyl)methyl]ami...)
Affinity DataIC50: 37nMAssay Description:Inhibition of human GHS receptor by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed