BDBM1934 3-[cyclopropyl(phenyl)methyl]-4-hydroxy-7-methoxy-2H-chromen-2-one::Carboxamide-Containing 4-Hydroxycoumarin analogue XV

SMILES COc1ccc2c(O)c(C(C3CC3)c3ccccc3)c(=O)oc2c1

InChI Key InChIKey=DXXWPNILFQDFMJ-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 1934   

TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Upjohn

LigandPNGBDBM1934(3-[cyclopropyl(phenyl)methyl]-4-hydroxy-7-methoxy-...)
Affinity DataKi:  170nM ΔG°:  -9.14kcal/molepH: 5.0 T: 2°CAssay Description:HIV-1 protease was purified and refolded from E. coli inclusion bodies. The substrate used spans the p17-p24 processing site (R-V-S-Q-N-Y-P-I-V-Q-N-K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Universiti Sains Malaysia

Curated by ChEMBL
LigandPNGBDBM1934(3-[cyclopropyl(phenyl)methyl]-4-hydroxy-7-methoxy-...)
Affinity DataKi:  170nMAssay Description:Binding affinity to HIV-1 protease assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed