BDBM193081 US9193726, 69

SMILES C[C@@H]([C@@H]1CC[C@@H](O1)c1cc(F)c(Cl)cc1C(F)(F)F)N1CCn2c(ccc(-n3cnc(C)c3)c2=O)C1=O

InChI Key InChIKey=AKCDDYGYIGPEKL-UHFFFAOYSA-N

Data  6 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 193081   

TargetPresenilin-1(Human)
Pfizer

US Patent
LigandPNGBDBM193081(US9193726, 69)
Affinity DataIC50: 7.84nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2016
Entry Details
Go to US Patent

TargetPresenilin-1(Human)
Pfizer

US Patent
LigandPNGBDBM193081(US9193726, 69)
Affinity DataIC50: 8nMAssay Description:Inhibition of gamma-secretase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Pfizer

US Patent
LigandPNGBDBM193081(US9193726, 69)
Affinity DataEC50:  8nMAssay Description:Modulation of gamma-secretase in CHO cells expressing human APP assessed as reduction in amyloid beta (1 to 42 residues) production after 24 hrs by E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Pfizer

US Patent
LigandPNGBDBM193081(US9193726, 69)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of gamma secretase derived from human Hela cell membrane assessed as reduction in amyloid beta (1 to 40) production by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetBeta-secretase 1(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM193081(US9193726, 69)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetCathepsin D(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM193081(US9193726, 69)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of Cathepsin D (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetTrypsin(Human)
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM193081(US9193726, 69)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of Trypsin (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed