BDBM193021 US9193726, 9

SMILES C[C@@H]([C@@H]1CC[C@@H](O1)c1ccc(Cl)cc1C(F)(F)F)N1CCn2c(ccc(-n3cnc(C)c3)c2=O)C1=O

InChI Key InChIKey=MUDLWRHYTYCFBR-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 193021   

TargetPresenilin-1(Human)
Pfizer

US Patent
LigandPNGBDBM193021(US9193726, 9)
Affinity DataIC50: 9.10nMT: 2°CAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2016
Entry Details
Go to US Patent

TargetPresenilin-1(Human)
Pfizer

US Patent
LigandPNGBDBM193021(US9193726, 9)
Affinity DataIC50: 9nMAssay Description:Inhibition of gamma-secretase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Pfizer

US Patent
LigandPNGBDBM193021(US9193726, 9)
Affinity DataEC50:  9nMAssay Description:Modulation of gamma-secretase in CHO cells expressing human APP assessed as reduction in amyloid beta (1 to 42 residues) production after 24 hrs by E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed