BDBM192946 US11072611, Compound 141::US9670204, 141 2-((2-ethyl-6-(1-(2-(3-hydroxyazetidin-1-yl)-2-oxoethyl)piperidin-4-yl)imidazo[1,2-a]pyridin-3-yl)(methyl)amino)-4-(4-fluorophenyl)thiazole-5-carbonitrile

SMILES CCc1nc2ccc(cn2c1N(C)c1nc(c(s1)C#N)-c1ccc(F)cc1)C1CCN(CC(=O)N2CC(O)C2)CC1

InChI Key InChIKey=USTXXAKVNIABFI-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 192946   

TargetAutotaxin(Human)
Galapagos

US Patent
LigandPNGBDBM192946(US9670204, 141 2-((2-ethyl-6-(1-(2-(3-hydroxyazeti...)
Affinity DataIC50: 50nMpH: 8.5 T: 2°CAssay Description:Compound IC50 values are determined in a hENPP2 (UniProtKB/SwissProt Sequence ref Q13822) biochemical assay using LPC as substrate. 5 μL of a di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
Go to US Patent

TargetAutotaxin(Rat)
Galapagos

Curated by ChEMBL
LigandPNGBDBM192946(US9670204, 141 2-((2-ethyl-6-(1-(2-(3-hydroxyazeti...)
Affinity DataIC50: 22nMAssay Description:Inhibition of ATX in rat plasma assessed as reduction in plasma lysophosphatidic acid 18:2 levels after 2 hrs by LC-MS/MS methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2019
Entry Details Article
PubMed
TargetAutotaxin(Human)
Galapagos

US Patent
LigandPNGBDBM192946(US9670204, 141 2-((2-ethyl-6-(1-(2-(3-hydroxyazeti...)
Affinity DataIC50: 27nMAssay Description:Inhibition of glycosylated human ATX using LPC 16:0 as substrate after 30 mins by luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2019
Entry Details Article
PubMed
LigandPNGBDBM192946(US9670204, 141 2-((2-ethyl-6-(1-(2-(3-hydroxyazeti...)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of human ERG by automated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2020
Entry Details Article
PubMed
TargetAutotaxin(Human)
Galapagos

US Patent
LigandPNGBDBM192946(US9670204, 141 2-((2-ethyl-6-(1-(2-(3-hydroxyazeti...)
Affinity DataIC50: 27nMAssay Description:Inhibition of human ATX using LPC (16:0) as substrate after 30 mins by horseradish peroxidase/choline oxidase coupled enzyme based spectrophotometric...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2020
Entry Details Article
PubMed
TargetAutotaxin(Rat)
Galapagos

Curated by ChEMBL
LigandPNGBDBM192946(US9670204, 141 2-((2-ethyl-6-(1-(2-(3-hydroxyazeti...)
Affinity DataIC50: 22nMAssay Description:Inhibition of ATX in rat plasma assessed as reduction in LPA 18:2 production after 2 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2020
Entry Details Article
PubMed
TargetAutotaxin(Human)
Galapagos

US Patent
LigandPNGBDBM192946(US9670204, 141 2-((2-ethyl-6-(1-(2-(3-hydroxyazeti...)
Affinity DataIC50: 27nMAssay Description:Inhibition of glycosylated human ATX using LPC 16:0 as substrate after 30 mins by luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2019
Entry Details Article
PubMed
TargetAutotaxin(Human)
Galapagos

US Patent
LigandPNGBDBM192946(US9670204, 141 2-((2-ethyl-6-(1-(2-(3-hydroxyazeti...)
Affinity DataIC50: 50nMAssay Description:TABLE V: 5 μL of a dilution series of compound, starting from 20 μM highest concentration, 1/5 dilution, is added to the wells. hENPP2 is u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2022
Entry Details
Go to US Patent

TargetAutotaxin(Human)
Galapagos

US Patent
LigandPNGBDBM192946(US9670204, 141 2-((2-ethyl-6-(1-(2-(3-hydroxyazeti...)
Affinity DataIC50: 50nMAssay Description:TABLE VI: (UniProtKB/SwissProt Sequence ref Q13822) biochemical assay using the fluorogenic autotaxin substrate FS-3 as substrate. FS-3 is a doubly l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2022
Entry Details
Go to US Patent