BDBM19238 2-{2-chloro-5-[4-({[(2,4-difluorophenyl)methyl](3-methanesulfonamido-2-methylphenyl)amino}methyl)phenoxy]phenoxy}acetic acid::GR sulfonamide modulator, 15

SMILES Cc1c(NS(C)(=O)=O)cccc1N(Cc1ccc(Oc2ccc(Cl)c(OCC(O)=O)c2)cc1)Cc1ccc(F)cc1F

InChI Key InChIKey=USLSTEHVCOVPEK-UHFFFAOYSA-N

Data  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 19238   

TargetGlucocorticoid receptor(Human)
Abbott Laboratories

LigandPNGBDBM19238(2-{2-chloro-5-[4-({[(2,4-difluorophenyl)methyl](3-...)
Affinity DataIC50: 2.60nM EC50:  500nMpH: 8.0 T: 2°CAssay Description:For compounds able to displace the 3(H)-dexamethasone from the receptor an IC50 value (the concentration required to inhibit 50% of the binding of 3(...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2007
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Rat)
Abbott Laboratories

LigandPNGBDBM19238(2-{2-chloro-5-[4-({[(2,4-difluorophenyl)methyl](3-...)
Affinity DataIC50: 1.90nMpH: 8.0 T: 2°CAssay Description:For compounds able to displace the radiolabeled ligand (competitor) from the receptor an IC50 value (the concentration required to inhibit 50% of the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2007
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Abbott Laboratories

LigandPNGBDBM19238(2-{2-chloro-5-[4-({[(2,4-difluorophenyl)methyl](3-...)
Affinity DataIC50: 150nMpH: 8.0 T: 2°CAssay Description:For compounds able to displace the radiolabeled ligand (competitor) from the receptor an IC50 value (the concentration required to inhibit 50% of the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2007
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Abbott Laboratories

LigandPNGBDBM19238(2-{2-chloro-5-[4-({[(2,4-difluorophenyl)methyl](3-...)
Affinity DataIC50: 3.60E+3nMpH: 8.0 T: 2°CAssay Description:For compounds able to displace the radiolabeled ligand (competitor) from the receptor an IC50 value (the concentration required to inhibit 50% of the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2007
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Abbott Laboratories

LigandPNGBDBM19238(2-{2-chloro-5-[4-({[(2,4-difluorophenyl)methyl](3-...)
Affinity DataIC50: 1.00E+3nMpH: 8.0 T: 2°CAssay Description:For compounds able to displace the radiolabeled ligand (competitor) from the receptor an IC50 value (the concentration required to inhibit 50% of the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2007
Entry Details Article
PubMed