BDBM191758 US9187397, 1 (curcumin)::US9187397, 3a

SMILES COc1cc(\C=C\C(\O)=C\C(=O)\C=C\c2ccc(O)c(OC)c2)ccc1O

InChI Key InChIKey=ZIUSSTSXXLLKKK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 191758   

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Stc.Unm

US Patent
LigandPNGBDBM191758(US9187397, 1 (curcumin) | US9187397, 3a)
Affinity DataIC50: 8.20E+3nMAssay Description:The NF-kB activities of curcumin and analogs were determined by a cellular firefly luciferase assay. This assay utilized a commercially available cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
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TargetTranscription factor Jun(Human)
Stc.Unm

US Patent
LigandPNGBDBM191758(US9187397, 1 (curcumin) | US9187397, 3a)
Affinity DataIC50: 1.28E+4nMAssay Description:Curcumin is a known inhibitor of the AP-1 activation cascade. Therefore, modification of the structure of curcumin could lead to analogs with enhance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
Go to US Patent