BDBM191748 US9187397, 20m

SMILES COc1ccc(OC)c(\C=C\C(=O)\C=C\c2cc(OC)ccc2OC)c1

InChI Key InChIKey=SXCNUJCWUYAUNK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 191748   

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Stc.Unm

US Patent
LigandPNGBDBM191748(US9187397, 20m)
Affinity DataIC50: 6.40E+3nMAssay Description:The NF-kB activities of curcumin and analogs were determined by a cellular firefly luciferase assay. This assay utilized a commercially available cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
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TargetTranscription factor Jun(Human)
Stc.Unm

US Patent
LigandPNGBDBM191748(US9187397, 20m)
Affinity DataIC50: 1.40E+3nMAssay Description:Curcumin is a known inhibitor of the AP-1 activation cascade. Therefore, modification of the structure of curcumin could lead to analogs with enhance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
Go to US Patent