BDBM191746 US9187397, 20q

SMILES Oc1ccccc1\C=C\C(=O)\C=C\c1ccccc1O

InChI Key InChIKey=YNVAHBUBGBLIEY-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 191746   

TargetNuclear factor NF-kappa-B p105 subunit(Human)
Stc.Unm

US Patent
LigandPNGBDBM191746(US9187397, 20q)
Affinity DataIC50: 4.20E+3nMAssay Description:The NF-kB activities of curcumin and analogs were determined by a cellular firefly luciferase assay. This assay utilized a commercially available cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
Go to US Patent

TargetTranscription factor Jun(Human)
Stc.Unm

US Patent
LigandPNGBDBM191746(US9187397, 20q)
Affinity DataIC50: 1.17E+4nMAssay Description:Curcumin is a known inhibitor of the AP-1 activation cascade. Therefore, modification of the structure of curcumin could lead to analogs with enhance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
Go to US Patent

TargetNuclear factor erythroid 2-related factor 2(Human)
University of New Mexico

Curated by ChEMBL
LigandPNGBDBM191746(US9187397, 20q)
Affinity DataEC50:  3.30E+3nMAssay Description:Activation of Nrf2 (unknown origin) expressed in human HepG2 cells after 5 hrs by ARE-driven luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2020
Entry Details Article
PubMed