BDBM191414 US9181272, 184::US9181272, 195::US9181272, 196

SMILES NC(=O)N1CCCc2cc(cnc12)-c1cncc(c1)C(O)C(F)(F)F

InChI Key InChIKey=STFOWNMXAVNANZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 191414   

TargetCytochrome P450 family 11 subfamily B member 2(Green monkey)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM191414(US9181272, 196 | US9181272, 195 | US9181272, 184)
Affinity DataIC50: 5.20nMpH: 7.4Assay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2016
Entry Details
Go to US Patent

TargetCytochrome P450 family 11 subfamily B member 2(Green monkey)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM191414(US9181272, 196 | US9181272, 195 | US9181272, 184)
Affinity DataIC50: 4.30nMpH: 7.4Assay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2016
Entry Details
Go to US Patent

TargetCytochrome P450 family 11 subfamily B member 2(Green monkey)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM191414(US9181272, 196 | US9181272, 195 | US9181272, 184)
Affinity DataIC50: 2.60nMpH: 7.4Assay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2016
Entry Details
Go to US Patent