BDBM190575 US9181219, 1-(1,2,3,4-tetrahydroquinolin-1-yl)-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfanyl}ethan-1-one

SMILES FC(F)(F)c1ccc(SCC(=O)N2CCCc3ccccc23)nc1

InChI Key InChIKey=MLUNKIGCWNPKQH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 190575   

LigandPNGBDBM190575(US9181219, 1-(1,2,3,4-tetrahydroquinolin-1-yl)-2-{...)
Affinity DataIC50: 5.00E+3nMAssay Description:TRPV3 cells were induced 20-48 hours, removed from growth plates, and replated at low density (to attain good single-cell physical separation) on gla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2016
Entry Details
Go to US Patent

LigandPNGBDBM190575(US9181219, 1-(1,2,3,4-tetrahydroquinolin-1-yl)-2-{...)
Affinity DataIC50: 1.00E+3nMAssay Description:TRPV3 cells were induced 20-48 hours, removed from growth plates, and replated at low density (to attain good single-cell physical separation) on gla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2016
Entry Details
Go to US Patent

TargetSodium channel protein type 2 subunit alpha(Human)
Hydra Biosciences

US Patent
LigandPNGBDBM190575(US9181219, 1-(1,2,3,4-tetrahydroquinolin-1-yl)-2-{...)
Affinity DataIC50: 3.00E+4nMAssay Description:TRPV3 cells were induced 20-48 hours, removed from growth plates, and replated at low density (to attain good single-cell physical separation) on gla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2016
Entry Details
Go to US Patent