BDBM190405 US9180183, Quinidine

SMILES COc1ccc2nccc([C@H](O)C3CC4CCN3C[C@@H]4C=C)c2c1

InChI Key

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 190405   

TargetCytochrome P450 2D6(Human)
Telormedix

US Patent
LigandPNGBDBM190405(US9180183, Quinidine)
Affinity DataIC50: 9nMAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2016
Entry Details
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TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandPNGBDBM190405(US9180183, Quinidine)
Affinity DataEC50:  2.41E+4nMpH: 7.3 T: 2°CAssay Description:The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2016
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Telormedix

US Patent
LigandPNGBDBM190405(US9180183, Quinidine)
Affinity DataIC50: 9nMT: 2°CAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2016
Entry Details
Go to US Patent

TargetCytochrome P450 2D6(Human)
Telormedix

US Patent
LigandPNGBDBM190405(US9180183, Quinidine)
Affinity DataIC50: 40nMpH: 7.4Assay Description:Specific aspects of the incubation conditions for each assay (e.g., protein concentration, incubation time, etc.) are defined in Walsky & Obach, 2004...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2018
Entry Details
Go to US Patent