BDBM190307 US10227346, Example 66::US10426135, Example 66::US9670201, 66 (R)-3-cyano-N-(3-(1-isobutyryl-2,2-dimethylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)benzamide::US9920054, Example 66

SMILES CC(C)C(=O)N1CC[C@H](CC1(C)C)c1cn(C)c2ncc(NC(=O)c3cccc(c3)C#N)c(c12)C(F)(F)F

InChI Key InChIKey=OLWRKMMKXIAXFV-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 190307   

TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandPNGBDBM190307(US9670201, 66 (R)-3-cyano-N-(3-(1-isobutyryl-2,2-d...)
Affinity DataIC50: 7.40nMpH: 7.5 T: 2°CAssay Description:Specifically, in one embodiment the aforementioned assay was performed as outlined below. The assay was carried out in black polystyrene, 384-well pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2018
Entry Details
Go to US Patent

TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandPNGBDBM190307(US9670201, 66 (R)-3-cyano-N-(3-(1-isobutyryl-2,2-d...)
Affinity DataIC50: 7.40nMAssay Description:The activity of compound of the invention can be determined by a co-activator recruitment by TR-FRET (time-resolved fluorescence resonance energy tra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandPNGBDBM190307(US9670201, 66 (R)-3-cyano-N-(3-(1-isobutyryl-2,2-d...)
Affinity DataIC50: 7.40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
Go to US Patent

TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandPNGBDBM190307(US9670201, 66 (R)-3-cyano-N-(3-(1-isobutyryl-2,2-d...)
Affinity DataIC50: 7.40nMAssay Description:The activity of compound of the invention can be determined by a co-activator recruitment by TR-FRET (time-resolved fluorescence resonance energy tra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details
Go to US Patent