BDBM18949 2-(3,5-dibromo-4-{4-hydroxy-3-[(3-phenylpropyl)carbamoyl]phenoxy}phenyl)acetic acid::4-hydroxy thyromimetic, 15d

SMILES OC(=O)Cc1cc(Br)c(Oc2ccc(O)c(c2)C(=O)NCCCc2ccccc2)c(Br)c1

InChI Key InChIKey=XYJAEXLTNMFZDJ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 18949   

TargetThyroid hormone receptor alpha(Human)
Bristol-Myers Squibb

LigandPNGBDBM18949(2-(3,5-dibromo-4-{4-hydroxy-3-[(3-phenylpropyl)car...)
Affinity DataIC50: 203nMAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRalpha. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2007
Entry Details Article
PubMed
TargetThyroid hormone receptor beta(Human)
Bristol-Myers Squibb

LigandPNGBDBM18949(2-(3,5-dibromo-4-{4-hydroxy-3-[(3-phenylpropyl)car...)
Affinity DataIC50: 6.80nMAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRalpha. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2007
Entry Details Article
PubMed
TargetThyroid hormone receptor beta(Human)
Bristol-Myers Squibb

LigandPNGBDBM18949(2-(3,5-dibromo-4-{4-hydroxy-3-[(3-phenylpropyl)car...)
Affinity DataIC50: 6.76nMAssay Description:Inhibition of human thyroid hormone receptor beta 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetThyroid hormone receptor beta(Human)
Bristol-Myers Squibb

LigandPNGBDBM18949(2-(3,5-dibromo-4-{4-hydroxy-3-[(3-phenylpropyl)car...)
Affinity DataIC50: 6.76nMAssay Description:Inhibition of thyroid hormone receptor betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Bristol-Myers Squibb

LigandPNGBDBM18949(2-(3,5-dibromo-4-{4-hydroxy-3-[(3-phenylpropyl)car...)
Affinity DataIC50: 204nMAssay Description:Inhibition of thyroid hormone receptor alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed