BDBM189434 US9174974, Example 19

SMILES C[C@H]1COC(=O)Nc2ccc(c(CN(C)C(=O)[C@H](Nc3ccc4c(N)ncc(F)c4c3)c3ccc1c(C)c3)c2)S(=O)(=O)C1CC1

InChI Key InChIKey=ZVYUEFHDJYEETD-UHFFFAOYSA-N

Data  14 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 189434   

TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM189434(US9174974, Example 19)
Affinity DataKi:  0.430nMAssay Description:FVIIa-Xase Ki (37° C.): S2765 (0.5 mM), PCPS (25 μM), calcium chloride (5 mM), full-length human TF (3 nM), human FVIIa (5 pM), and FVIIa inhibi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
Go to US Patent

TargetCoagulation factor VII/Tissue factor(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM189434(US9174974, Example 19)
Affinity DataKi:  0.430nMAssay Description:Inhibition of full-length human TF/recombinant human factor 7a assessed as decrease in conversion of factor 10 to factor 10a by measuring S2765 hydro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2018
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM189434(US9174974, Example 19)
Affinity DataKi:  190nMAssay Description:Inhibition of human activated protein C using pyroGlu-Pro-Arg-pNA as substrate assessed as release of pNA after 10 to 120 mins by spectrophotometric ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2018
Entry Details Article
PubMed
TargetPlasma kallikrein(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM189434(US9174974, Example 19)
Affinity DataKi:  520nMAssay Description:Inhibition of human plasma kallikrein using H-(D)-Pro-Phe-Arg-pNA as substrate assessed as release of pNA after 10 to 120 mins by spectrophotometric ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2018
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM189434(US9174974, Example 19)
Affinity DataKi:  650nMpH: 7.4Assay Description:Tissue kallikrein-1 (37° C) activity was determined in reactions containing 0.05 nM enzyme and 90 μM substrate (H-D-Val-Leu-Arg-AFC) in buffer (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2016
Entry Details
Go to US Patent

TargetKallikrein-1(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM189434(US9174974, Example 19)
Affinity DataKi:  650nMAssay Description:Inhibition of human HK1 using H-D-Val-Leu-Arg-AFC as substrate assessed as release of AFC after 10 to 120 mins by spectrofluorimetric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2018
Entry Details Article
PubMed
TargetPlasminogen(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM189434(US9174974, Example 19)
Affinity DataKi:  1.50E+3nMAssay Description:Inhibition of human plasmin using H-(D)-Val-Leu-LyspNA as substrate assessed as release of pNA after 10 to 120 mins by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2018
Entry Details Article
PubMed
TargetCoagulation factor IX(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM189434(US9174974, Example 19)
Affinity DataKi:  1.60E+3nMAssay Description:Inhibition of human factor 9a using methylsulfonyl-D-cyclohexylglycyl-Gly-Arg-AMC as substrate assessed as release of AMC after 10 to 120 mins by spe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2018
Entry Details Article
PubMed
TargetCoagulation factor XI(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM189434(US9174974, Example 19)
Affinity DataKi:  3.40E+3nMAssay Description:Inhibition of human factor 11a using pyroGlu-Pro-Arg-pNA as substrate assessed as release of pNA after 10 to 120 mins by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2018
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM189434(US9174974, Example 19)
Affinity DataKi:  4.00E+3nMAssay Description:Inhibition of human factor 10a using N-benzoyl-Ile-Glu-(OH,OMe)-Gly-Arg-pNA as substrate assessed as release of pNA after 10 to 120 mins by spectroph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2018
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM189434(US9174974, Example 19)
Affinity DataKi:  7.50E+3nMAssay Description:Inhibition of human factor 12a using H-(D)-CHT-Gly-Arg-pNA as substrate assessed as release of pNA after 10 to 120 mins by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2018
Entry Details Article
PubMed
TargetTissue-type plasminogen activator(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM189434(US9174974, Example 19)
Affinity DataKi:  9.10E+3nMAssay Description:Inhibition of human recombinant tPA using methylsulfonyl-D-cyclohexylalanylGly-Arg-pNA as substrate assessed as release of pNA after 10 to 120 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2018
Entry Details Article
PubMed
TargetProthrombin(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM189434(US9174974, Example 19)
Affinity DataKi:  1.10E+4nMAssay Description:Inhibition of alpha-thrombin (unknown origin) using pyroGlu-Pro-Arg-pNA as substrate assessed as release of pNA after 10 to 120 mins by spectrophotom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2018
Entry Details Article
PubMed
TargetUrokinase-type plasminogen activator(Human)
Bristol-Myers Squibb R & D

Curated by ChEMBL
LigandPNGBDBM189434(US9174974, Example 19)
Affinity DataKi:  1.50E+4nMAssay Description:Inhibition of human urokinase using pyro-Glu-Gly-Arg-pNA as substrate assessed as release of pNA after 10 to 120 mins by spectrophotometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2018
Entry Details Article
PubMed