BDBM18938 2-[3,5-dibromo-4-(4-hydroxy-3-phenoxyphenoxy)phenyl]acetic acid::4-hydroxy thyromimetic, 13a

SMILES OC(=O)Cc1cc(Br)c(Oc2ccc(O)c(Oc3ccccc3)c2)c(Br)c1

InChI Key InChIKey=NHYQPCDQZSMCBN-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 18938   

TargetThyroid hormone receptor alpha(Human)
Bristol-Myers Squibb

LigandPNGBDBM18938(2-[3,5-dibromo-4-(4-hydroxy-3-phenoxyphenoxy)pheny...)
Affinity DataIC50: 123nMAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRalpha. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2007
Entry Details Article
PubMed
TargetThyroid hormone receptor beta(Human)
Bristol-Myers Squibb

LigandPNGBDBM18938(2-[3,5-dibromo-4-(4-hydroxy-3-phenoxyphenoxy)pheny...)
Affinity DataIC50: 5.97nMAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRalpha. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2007
Entry Details Article
PubMed
TargetThyroid hormone receptor beta(Human)
Bristol-Myers Squibb

LigandPNGBDBM18938(2-[3,5-dibromo-4-(4-hydroxy-3-phenoxyphenoxy)pheny...)
Affinity DataIC50: 6.03nMAssay Description:Inhibition of human thyroid hormone receptor beta 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetThyroid hormone receptor beta(Human)
Bristol-Myers Squibb

LigandPNGBDBM18938(2-[3,5-dibromo-4-(4-hydroxy-3-phenoxyphenoxy)pheny...)
Affinity DataIC50: 6.03nMAssay Description:Inhibition of thyroid hormone receptor betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Bristol-Myers Squibb

LigandPNGBDBM18938(2-[3,5-dibromo-4-(4-hydroxy-3-phenoxyphenoxy)pheny...)
Affinity DataIC50: 123nMAssay Description:Inhibition of thyroid hormone receptor alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed