BDBM18624 (18Z)-18-({3-[(1E)-1-(ethoxyimino)ethyl]thiophen-2-yl}methylidene)-12-methoxy-3,5,5-trimethyl-17-oxa-6-azatetracyclo[8.8.0.0^{2,7}.0^{11,16}]octadeca-1(10),2(7),3,8,11,13,15-heptaen-13-ol::Oxime, 24

SMILES CCO\N=C(/C)c1ccsc1\C=C1/Oc2ccc(O)c(OC)c2-c2ccc3NC(C)(C)C=C(C)c3c12

InChI Key InChIKey=KBVWGNZJBRNUFG-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 18624   

TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18624((18Z)-18-({3-[(1E)-1-(ethoxyimino)ethyl]thiophen-2...)
Affinity DataIC50: 0.5nM EC50:  1.90nMpH: 7.5Assay Description:GR-Mediated Antagonist Activity Assay- GR-mediated antagonist activity is measured in the presence of a concentration of dexamethasone empirically de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2007
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM18624((18Z)-18-({3-[(1E)-1-(ethoxyimino)ethyl]thiophen-2...)
Affinity DataIC50: 0.5nM EC50:  0.400nMpH: 7.5Assay Description:GR-Mediated Agonist Activity Assay- GR-mediated activation by compounds is measured against maximal activation of dexamethasone in the same experimen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2007
Entry Details Article
PubMed