BDBM186048 US9163011, 2

SMILES C[C@@]1(N=C(N)OCC1(F)F)c1nc(NC(=O)c2ncc(cc2Cl)C#N)ccc1F

InChI Key InChIKey=XZRLHXIFWZKMCO-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 186048   

TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandPNGBDBM186048(US9163011, 2)
Affinity DataIC50: 12nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 1 nM concentrations is incubated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2016
Entry Details
Go to US Patent

TargetBeta-secretase 2(Human)
Novartis

US Patent
LigandPNGBDBM186048(US9163011, 2)
Affinity DataIC50: 71nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-2 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 1 nM concentrations is incubated wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2016
Entry Details
Go to US Patent

TargetAmyloid-beta precursor protein(Human)
Novartis

US Patent
LigandPNGBDBM186048(US9163011, 2)
Affinity DataIC50: 8nMAssay Description:Chinese hamster ovary cells are transfected with the human gene for amyloid precursor protein. The cells are plated at a density of 8000 cells/well i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2016
Entry Details
Go to US Patent

TargetBeta-secretase 2(Human)
Novartis

US Patent
LigandPNGBDBM186048(US9163011, 2)
Affinity DataIC50: 71nMAssay Description:Inhibition of recombinant human BACE2 extracellular domain expressed in baculovirus using Q-C(HS03)-lle-Asp-Leu-Ala-Val-Leu-Asp-HN-CH2-CH2-Mca as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetBeta-secretase 1/2(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM186048(US9163011, 2)
Affinity DataIC50: 8nMAssay Description:Inhibition of BACE1/BACE2 (unknown origin) transfected in CHO cells assessed as release of amyloid beta (1 to 40) after 24 hrs by immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandPNGBDBM186048(US9163011, 2)
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant human BACE1 extracellular domain expressed in baculovirus using Q-C(HS03)-lle-Asp-Leu-Ala-Val-Leu-Asp-HN-CH2-CH2-Mca as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandPNGBDBM186048(US9163011, 2)
Affinity DataIC50: 12nMAssay Description:Inhibition of human BACE1 expressed in baculovirus expression system using Q-C(HS03)-lle-Asp-Leu-Ala-Val-Leu-Asp-HN-CH2-CH2-Mca as substrate incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Novartis

US Patent
LigandPNGBDBM186048(US9163011, 2)
Affinity DataIC50: 71nMAssay Description:Inhibition of human BACE2 expressed in baculovirus expression system using Q-C(HS03)-lle-Asp-Leu-Ala-Val-Leu-Asp-HN-CH2-CH2-Mca as substrate incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetBeta-secretase 1(Chinese hamster)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM186048(US9163011, 2)
Affinity DataIC50: 8nMAssay Description:Inhibition of BACE1 in CHO cells expressing human APP assessed as reduction in amyloidbeta (1 to 40 residues) level incubated for 24 hrs by immunoass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed