BDBM185820 US9163003, 32::USRE46942, Example 32

SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(CC(=O)Nc2nnc3SCCn23)C1=O

InChI Key InChIKey=PADREXIRIZBNMQ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 185820   

TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Novartis

US Patent
LigandPNGBDBM185820(US9163003, 32 | USRE46942, Example 32)
Affinity DataIC50: 21nMT: 2°CAssay Description:The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2016
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
Novartis

US Patent
LigandPNGBDBM185820(US9163003, 32 | USRE46942, Example 32)
Affinity DataIC50: 43nMT: 2°CAssay Description:The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2016
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Novartis

US Patent
LigandPNGBDBM185820(US9163003, 32 | USRE46942, Example 32)
Affinity DataIC50: 1.90E+4nMT: 2°CAssay Description:The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2016
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 2(Human)
Novartis

US Patent
LigandPNGBDBM185820(US9163003, 32 | USRE46942, Example 32)
Affinity DataIC50: 5.09E+3nMT: 2°CAssay Description:The autoparsylation activity of the TNKS 1/2 or PARP1/2 enzymes was measured by the liquid chromatography-mass spectrometry (LC/MS) detection of nico...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2016
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Novartis

US Patent
LigandPNGBDBM185820(US9163003, 32 | USRE46942, Example 32)
Affinity DataIC50: 21nMAssay Description:The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
Novartis

US Patent
LigandPNGBDBM185820(US9163003, 32 | USRE46942, Example 32)
Affinity DataIC50: 43nMAssay Description:The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Novartis

US Patent
LigandPNGBDBM185820(US9163003, 32 | USRE46942, Example 32)
Affinity DataIC50: 1.90E+4nMAssay Description:The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent

TargetPoly [ADP-ribose] polymerase 2(Human)
Novartis

US Patent
LigandPNGBDBM185820(US9163003, 32 | USRE46942, Example 32)
Affinity DataIC50: 5.09E+3nMAssay Description:The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
US Patent