BDBM1857 3-[(2-tert-Butyl-5-methylphenyl)sulfanyl]-5,6-dihydro-4-hydroxy-6,6-diphenyl-2H-pyran-2-one::3-[(2-tert-butyl-5-methylphenyl)sulfanyl]-4-hydroxy-6,6-diphenyl-5,6-dihydro-2H-pyran-2-one::4-Hydroxy-5,6-dihydropyrone deriv. 48

SMILES Cc1ccc(c(SC2C(=O)CC(OC2=O)(c2ccccc2)c2ccccc2)c1)C(C)(C)C

InChI Key InChIKey=WSKZFZHVJVDGGU-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 1857   

TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM1857(3-[(2-tert-butyl-5-methylphenyl)sulfanyl]-4-hydrox...)
Affinity DataIC50: 12nMAssay Description:For determination of IC50 values, HIV-1 protease was added to assay buffer containing inhibitor and the substrate (H-His-Lys-Ala-Arg-Val-Leu- (p-NO2)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2004
Entry Details Article
PubMed