BDBM184561 US9150581, RTI-7527-(+/-)-102::US9150581, RTI-7527-(-)-102

SMILES Fc1ncc(cc1-c1ccc(cc1)N(=O)=O)C1CC2CCC1N2

InChI Key

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 184561   

LigandPNGBDBM184561(US9150581, RTI-7527-(-)-102 | US9150581, RTI-7527-...)
Affinity DataKi:  0.00900nMAssay Description:The Ki values for the inhibition of [3H]epibatidine binding at the α4β2 nAChR in male rat cerebral cortex for compounds are listed in Table...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2016
Entry Details
Go to US Patent

LigandPNGBDBM184561(US9150581, RTI-7527-(-)-102 | US9150581, RTI-7527-...)
Affinity DataKi:  0.0210nMAssay Description:The Ki values for the inhibition of [3H]epibatidine binding at the α4β2 nAChR in male rat cerebral cortex for compounds are listed in Table...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2016
Entry Details
Go to US Patent

LigandPNGBDBM184561(US9150581, RTI-7527-(-)-102 | US9150581, RTI-7527-...)
Affinity DataKi:  0.0220nMAssay Description:The Ki values for the inhibition of [3H]epibatidine binding at the α4β2 nAChR in male rat cerebral cortex for compounds are listed in Table...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2016
Entry Details
Go to US Patent

TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Research Triangle Institute

US Patent
LigandPNGBDBM184561(US9150581, RTI-7527-(-)-102 | US9150581, RTI-7527-...)
Affinity DataKi: >2.00E+3nMAssay Description:Compounds (10 mM) were also evaluated for inhibition of binding to a7 nAChR using [125I]iodoMLA as previously reported in Carroll et al. The binding ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2016
Entry Details
Go to US Patent