BDBM18405 (3R,5S)-6-[(3-{[(3-chlorophenyl)methyl](methyl)carbamoyl}-1-(4-fluorophenyl)-4-(propan-2-yl)-1H-pyrazol-5-yl)oxy]-3,5-dihydroxyhexanoic acid::oxypyrazole, 4r

SMILES CC(C)c1c(OC[C@@H](O)C[C@@H](O)CC(O)=O)n(nc1C(=O)N(C)Cc1cccc(Cl)c1)-c1ccc(F)cc1

InChI Key InChIKey=QPHWZVSPNVFKJH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 18405   

LigandPNGBDBM18405((3R,5S)-6-[(3-{[(3-chlorophenyl)methyl](methyl)car...)
Affinity DataIC50: 8.30nMpH: 7.2 T: 2°CAssay Description:Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2007
Entry Details Article
PubMed