BDBM182759 US9145412, Table 1, Compound 48

SMILES Nc1ccc(cc1NC(=O)c1cnc2n(CCN3CCOCC3)c(cc2c1)C1CC1)-c1ccncc1

InChI Key InChIKey=GXWLJZUWPTZKSN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 182759   

TargetHistone deacetylase 1(Human)
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM182759(US9145412, Table 1, Compound 48)
Affinity DataIC50: 27nMpH: 7.4Assay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2016
Entry Details
Go to US Patent

TargetHistone deacetylase 2(Human)
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM182759(US9145412, Table 1, Compound 48)
Affinity DataIC50: 24nMpH: 7.4Assay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2016
Entry Details
Go to US Patent

TargetHistone deacetylase 3(Human)
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM182759(US9145412, Table 1, Compound 48)
Affinity DataIC50: 247nMpH: 7.4Assay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2016
Entry Details
Go to US Patent