BDBM182735 US10774056, Compound 001::US11542242, Compound 001::US9145412, Table 1, Compound 1

SMILES Nc1ccccc1NC(=O)c1ccc2nc(ccc2c1)N1CCNCC1

InChI Key InChIKey=BSYRUCVRUZESMD-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 182735   

TargetHistone deacetylase 1(Human)
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM182735(US9145412, Table 1, Compound 1 | US10774056, Compo...)
Affinity DataIC50: 2.00E+3nMpH: 7.4Assay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2016
Entry Details
Go to US Patent

TargetHistone deacetylase 2(Human)
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM182735(US9145412, Table 1, Compound 1 | US10774056, Compo...)
Affinity DataIC50: 624nMpH: 7.4Assay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2016
Entry Details
Go to US Patent

TargetHistone deacetylase 3(Human)
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM182735(US9145412, Table 1, Compound 1 | US10774056, Compo...)
Affinity DataIC50: 104nMpH: 7.4Assay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2016
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Regenacy Pharmaceuticals

US Patent
LigandPNGBDBM182735(US9145412, Table 1, Compound 1 | US10774056, Compo...)
Affinity DataIC50: 3.00E+4nMAssay Description:For hERG inhibition assays, the cells used were HEK293 cells stably transfected with hERG (cell line obtained from Cytocentrics Inc. 3463 Magic Drive...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Regenacy Pharmaceuticals

US Patent
LigandPNGBDBM182735(US9145412, Table 1, Compound 1 | US10774056, Compo...)
Affinity DataIC50: 3.00E+4nMAssay Description:For hERG inhibition assays, the cells used were HEK293 cells stably transfected with hERG (cell line obtained from Cytocentrics Inc. 3463 Magic Drive...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2023
Entry Details
Go to US Patent