BDBM18262 5-methyl-6-(naphthalen-2-ylsulfanyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine::Pyrrolo[2, 3-d]pyrimidine analogue, 1b

SMILES Cc1c(Sc2ccc3ccccc3c2)[nH]c2nc(N)nc(N)c12

InChI Key InChIKey=HYATWDPIRHVVDH-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 18262   

TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

LigandPNGBDBM18262(5-methyl-6-(naphthalen-2-ylsulfanyl)-7H-pyrrolo[2,...)
Affinity DataIC50: 3.73E+4nMAssay Description:Enzymatic activities were determined by monitoring the oxidation of NADPH at 340 nm using a 96-well microtiter plate reading spectrophotometer.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2007
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

LigandPNGBDBM18262(5-methyl-6-(naphthalen-2-ylsulfanyl)-7H-pyrrolo[2,...)
Affinity DataIC50: 160nMAssay Description:Enzymatic activities were determined by monitoring the oxidation of NADPH at 340 nm using a 96-well microtiter plate reading spectrophotometer.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2007
Entry Details Article
PubMed
TargetDihydrofolate reductase(Mycobacterium avium)
Duquesne University

LigandPNGBDBM18262(5-methyl-6-(naphthalen-2-ylsulfanyl)-7H-pyrrolo[2,...)
Affinity DataIC50: 700nMAssay Description:Enzymatic activities were determined by monitoring the oxidation of NADPH at 340 nm using a 96-well microtiter plate reading spectrophotometer.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2007
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

LigandPNGBDBM18262(5-methyl-6-(naphthalen-2-ylsulfanyl)-7H-pyrrolo[2,...)
Affinity DataIC50: 4.57E+3nMAssay Description:Enzymatic activities were determined by monitoring the oxidation of NADPH at 340 nm using a 96-well microtiter plate reading spectrophotometer.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2007
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

LigandPNGBDBM18262(5-methyl-6-(naphthalen-2-ylsulfanyl)-7H-pyrrolo[2,...)
Affinity DataIC50: 8.10E+3nMAssay Description:Inhibition of rat liver DHFR using dihydrofolic acid substrate and NADPH cofactor by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

LigandPNGBDBM18262(5-methyl-6-(naphthalen-2-ylsulfanyl)-7H-pyrrolo[2,...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of Toxoplasma gondii DHFR using dihydrofolic acid substrate and NADPH cofactor by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human pneumocystis pneumonia agent)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18262(5-methyl-6-(naphthalen-2-ylsulfanyl)-7H-pyrrolo[2,...)
Affinity DataIC50: 101nMAssay Description:Inhibition of Pneumocystis jirovecii recombinant DHFR expressed in Escherichia coli Rosetta Gami B (DE3) competent cells using DHFA as substrate and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18262(5-methyl-6-(naphthalen-2-ylsulfanyl)-7H-pyrrolo[2,...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of human recombinant DHFR expressed in Escherichia coli Rosetta Gami B (DE3) competent cells using DHFA as substrate and NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed