BDBM18254 5-ethyl-6-[(4-methoxyphenyl)sulfanyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine::Pyrrolo[2, 3-d]pyrimidine analogue, 12

SMILES CCc1c(Sc2ccc(OC)cc2)[nH]c2nc(N)nc(N)c12

InChI Key InChIKey=NHSJLKXZIRAUEN-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 18254   

TargetDihydrofolate reductase(Escherichia coli (strain K12))
Duquesne University

LigandPNGBDBM18254(5-ethyl-6-[(4-methoxyphenyl)sulfanyl]-7H-pyrrolo[2...)
Affinity DataIC50: 320nMpH: 7.4 T: 2°CAssay Description:Enzymatic activities were determined by monitoring the oxidation of NADPH at 340 nm using a 96-well microtiter plate reading spectrophotometer.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2007
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Duquesne University

LigandPNGBDBM18254(5-ethyl-6-[(4-methoxyphenyl)sulfanyl]-7H-pyrrolo[2...)
Affinity DataIC50: 2.90E+3nMAssay Description:Enzymatic activities were determined by monitoring the oxidation of NADPH at 340 nm using a 96-well microtiter plate reading spectrophotometer.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2007
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

LigandPNGBDBM18254(5-ethyl-6-[(4-methoxyphenyl)sulfanyl]-7H-pyrrolo[2...)
Affinity DataIC50: 5.30E+4nMAssay Description:Enzymatic activities were determined by monitoring the oxidation of NADPH at 340 nm using a 96-well microtiter plate reading spectrophotometer.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2007
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

LigandPNGBDBM18254(5-ethyl-6-[(4-methoxyphenyl)sulfanyl]-7H-pyrrolo[2...)
Affinity DataIC50: 4.62E+3nMAssay Description:Enzymatic activities were determined by monitoring the oxidation of NADPH at 340 nm using a 96-well microtiter plate reading spectrophotometer.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2007
Entry Details Article
PubMed
TargetDihydrofolate reductase(Mycobacterium avium)
Duquesne University

LigandPNGBDBM18254(5-ethyl-6-[(4-methoxyphenyl)sulfanyl]-7H-pyrrolo[2...)
Affinity DataIC50: 3.07E+3nMAssay Description:Enzymatic activities were determined by monitoring the oxidation of NADPH at 340 nm using a 96-well microtiter plate reading spectrophotometer.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2007
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

LigandPNGBDBM18254(5-ethyl-6-[(4-methoxyphenyl)sulfanyl]-7H-pyrrolo[2...)
Affinity DataIC50: 3.18E+4nMAssay Description:Enzymatic activities were determined by monitoring the oxidation of NADPH at 340 nm using a 96-well microtiter plate reading spectrophotometer.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2007
Entry Details Article
PubMed