BDBM182372 US9145392, 73

SMILES CN(C)CCn1cc(nc1C1CCN(CC1)c1ncnc(N)c1C=C)-c1ccc(F)c(c1)C(F)(F)F

InChI Key InChIKey=GBOPQOSLCOHLCP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 182372   

TargetRAC-alpha serine/threonine-protein kinase(Human)
Merck Patent

US Patent
LigandPNGBDBM182372(US9145392, 73)
Affinity DataIC50: 7.90nMpH: 7.5Assay Description:A TTP Mosquito liquid handling instrument is used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2016
Entry Details
Go to US Patent

TargetRibosomal protein S6 kinase beta-1(Human)
Merck Patent

US Patent
LigandPNGBDBM182372(US9145392, 73)
Affinity DataIC50: 2.70nMpH: 7.5 T: 2°CAssay Description:P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2016
Entry Details
Go to US Patent

TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Human)
Emd Serono Research and Development Institute

Curated by ChEMBL
LigandPNGBDBM182372(US9145392, 73)
Affinity DataIC50: 9.10nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Emd Serono Research and Development Institute

Curated by ChEMBL
LigandPNGBDBM182372(US9145392, 73)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed