BDBM18233 6-[2-({2,4-diamino-5-methylpyrido[2,3-d]pyrimidin-6-yl}methyl)-4-methoxyphenyl]hex-5-ynoic acid::Piritrexim analogue, 14

SMILES Cc1c(cnc2c1c(nc(n2)N)N)Cc3cc(ccc3C#CCCCC(=O)O)OC

InChI Key InChIKey=MAWHZPJVFGJFTF-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 18233   

TargetDihydrofolate reductase(Pneumocystis carinii)
Harvard Medical School

LigandPNGBDBM18233(6-[2-({2,4-diamino-5-methylpyrido[2,3-d]pyrimidin-...)
Affinity DataIC50: 1.20nMpH: 7.4 T: 2°CAssay Description:Dihydrofolate reductase was assayed with no inhibitor and with a series of concentrations of inhibitors to allow for a range of inhibition from 10 to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Harvard Medical School

LigandPNGBDBM18233(6-[2-({2,4-diamino-5-methylpyrido[2,3-d]pyrimidin-...)
Affinity DataIC50: 5.80nMAssay Description:Dihydrofolate reductase was assayed with no inhibitor and with a series of concentrations of inhibitors to allow for a range of inhibition from 10 to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2007
Entry Details Article
PubMed
TargetDihydrofolate reductase(Mycobacterium avium)
Harvard Medical School

LigandPNGBDBM18233(6-[2-({2,4-diamino-5-methylpyrido[2,3-d]pyrimidin-...)
Affinity DataIC50: 1.30nMAssay Description:Dihydrofolate reductase was assayed with no inhibitor and with a series of concentrations of inhibitors to allow for a range of inhibition from 10 to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2007
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Harvard Medical School

LigandPNGBDBM18233(6-[2-({2,4-diamino-5-methylpyrido[2,3-d]pyrimidin-...)
Affinity DataIC50: 24nMAssay Description:Dihydrofolate reductase was assayed with no inhibitor and with a series of concentrations of inhibitors to allow for a range of inhibition from 10 to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2007
Entry Details Article
PubMed