BDBM182309 US9145392, 10

SMILES Cn1cc(nc1C1CCN(CC1)c1ncnc(N)c1-c1ccc(F)cc1)-c1ccc(F)c(c1)C(F)(F)F

InChI Key InChIKey=RYMJKFCEWNTOSX-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 182309   

TargetRAC-alpha serine/threonine-protein kinase(Human)
Merck Patent

US Patent
LigandPNGBDBM182309(US9145392, 10)
Affinity DataIC50: 2.20E+3nMpH: 7.5Assay Description:A TTP Mosquito liquid handling instrument is used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2016
Entry Details
Go to US Patent

TargetRibosomal protein S6 kinase beta-1(Human)
Merck Patent

US Patent
LigandPNGBDBM182309(US9145392, 10)
Affinity DataIC50: 3.40nMpH: 7.5 T: 2°CAssay Description:P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2016
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
Emd Serono Research and Development Institute

Curated by ChEMBL
LigandPNGBDBM182309(US9145392, 10)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Emd Serono Research and Development Institute

Curated by ChEMBL
LigandPNGBDBM182309(US9145392, 10)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Human)
Emd Serono Research and Development Institute

Curated by ChEMBL
LigandPNGBDBM182309(US9145392, 10)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Emd Serono Research and Development Institute

Curated by ChEMBL
LigandPNGBDBM182309(US9145392, 10)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Emd Serono Research and Development Institute

Curated by ChEMBL
LigandPNGBDBM182309(US9145392, 10)
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of CYP2B6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Emd Serono Research and Development Institute

Curated by ChEMBL
LigandPNGBDBM182309(US9145392, 10)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2C8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Emd Serono Research and Development Institute

Curated by ChEMBL
LigandPNGBDBM182309(US9145392, 10)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Emd Serono Research and Development Institute

Curated by ChEMBL
LigandPNGBDBM182309(US9145392, 10)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Emd Serono Research and Development Institute

Curated by ChEMBL
LigandPNGBDBM182309(US9145392, 10)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed