BDBM181147 MTH1 inhibitor, 88::US9138393, Kinetin::US9144538, Kinetin

SMILES C(Nc1ncnc2[nH]cnc12)c1ccco1

InChI Key InChIKey=QANMHLXAZMSUEX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 181147   

TargetCytochrome P450 3A4(Human)
The Procter & Gamble

US Patent
LigandPNGBDBM181147(US9138393, Kinetin | MTH1 inhibitor, 88 | US914453...)
Affinity DataIC50: 1.00E+4nMAssay Description:A commercially available P450-GLO Assay kit (Promega Corporation, Madison Wis.) is used to screen various compounds for CYP3A4A inhibition activity. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2016
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
The Procter & Gamble

US Patent
LigandPNGBDBM181147(US9138393, Kinetin | MTH1 inhibitor, 88 | US914453...)
Affinity DataIC50: 1.00E+4nMAssay Description:Cytochrome P450 is a large and diverse group of enzymes that catalyze the oxidation of organic substances. Some members of the CYP family contribute ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2016
Entry Details
Go to US Patent

TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Riken Center For Life Science Technologies

LigandPNGBDBM181147(US9138393, Kinetin | MTH1 inhibitor, 88 | US914453...)
Affinity DataIC50: 2.00E+4nMpH: 7.5Assay Description:Enzymatic reaction was initiated by adding either 8-oxo-dGTP (13.2 μm; TriLink BioTechnologies) or 2-OH-dATP (8.3 μm; Jena Bioscience) to r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2017
Entry Details Article
PubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Riken Center For Life Science Technologies

LigandPNGBDBM181147(US9138393, Kinetin | MTH1 inhibitor, 88 | US914453...)
Affinity DataIC50: 2.90E+4nMpH: 7.5Assay Description:Enzymatic reaction was initiated by adding either 8-oxo-dGTP (13.2 μm; TriLink BioTechnologies) or 2-OH-dATP (8.3 μm; Jena Bioscience) to r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2017
Entry Details Article
PubMed