BDBM181128 US9138393, Diltiazem

SMILES COc1ccc(cc1)[C@@H]1Sc2ccccc2N(C(C)N(C)C)C(=O)[C@@H]1OC(C)=O

InChI Key InChIKey=YHPPHZYGGIUDFA-UHFFFAOYSA-N

Data  1 IC50  1 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 181128   

TargetPotassium channel subfamily K member 2(Human)
Korea Institute of Science and Technology

LigandBDBM181128(US9138393, Diltiazem)Copy SMILESCopy InChI

Affinity DataEC50:  2.48E+4nMpH: 7.3 T: 2°CAssay Description:The hTREK1 stable cell lines were seeded at a density of 10 000 cells/well in a 12-well plate. Whole-cell membrane currents were amplified using the ...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
11/28/2016
Entry Details Article
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TargetCytochrome P450 3A4(Human)
The Procter & Gamble

US Patent

LigandBDBM181128(US9138393, Diltiazem)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:A commercially available P450-GLO Assay kit (Promega Corporation, Madison Wis.) is used to screen various compounds for CYP3A4A inhibition activity. ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/6/2016
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL