BDBM181062 (E)-N'-(3,5-Dichloro-2-hydroxybenzylidene)-4-(2-oxo-2Hchromen-3-yl)thiazole-2-carbohydrazide (7e)

SMILES Oc1c(Cl)cc(Cl)cc1\C=N\NC(=O)c1nc(cs1)-c1cc2ccccc2oc1=O

InChI Key InChIKey=DBCVETGEECJHRM-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 181062   

TargetAlpha-glucosidase MAL12(Baker's yeast)
Jishou University

LigandPNGBDBM181062((E)-N'-(3,5-Dichloro-2-hydroxybenzylidene)-4-(...)
Affinity DataIC50: 6.24E+3nMpH: 6.8Assay Description:The test compounds were dissolved in DMSO to prepare the required distributing concentration. α-Glucosidase inhibitory activity was assayed by u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2016
Entry Details Article
PubMed
TargetProbable maltase-glucoamylase 2(Human)
Babasaheb Bhimrao Ambedkar University (A Central University)

Curated by ChEMBL
LigandPNGBDBM181062((E)-N'-(3,5-Dichloro-2-hydroxybenzylidene)-4-(...)
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of alpha-glucosidase (unknown origin) using p-nitro phenyl glucopyranoside as substrate preincubated for 10 mins followed by substrate add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Quaid-I-Azam University

Curated by ChEMBL
LigandPNGBDBM181062((E)-N'-(3,5-Dichloro-2-hydroxybenzylidene)-4-(...)
Affinity DataIC50: 6.24E+3nMAssay Description:Inhibition of Saccharomyces cerevisiae alpha-glucosidase using p-nitrophenyl-alpha-D-glucopyranoside as substrate preincubated for 10 mins followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetProbable maltase-glucoamylase 2(Human)
Babasaheb Bhimrao Ambedkar University (A Central University)

Curated by ChEMBL
LigandPNGBDBM181062((E)-N'-(3,5-Dichloro-2-hydroxybenzylidene)-4-(...)
Affinity DataKi:  6.80E+3nMAssay Description:Non-competitive inhibition of alpha-glucosidase (unknown origin) using p-nitro phenyl glucopyranoside as substrate preincubated for 10 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Quaid-I-Azam University

Curated by ChEMBL
LigandPNGBDBM181062((E)-N'-(3,5-Dichloro-2-hydroxybenzylidene)-4-(...)
Affinity DataKi:  6.86E+3nMAssay Description:Non-competitive inhibition of Saccharomyces cerevisiae alpha-glucosidase using p-nitrophenyl-alpha-D-glucopyranoside as substrate assessed as inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed