BDBM181037 US9133183, Example 42

SMILES CCN1CCN(C(=O)Nc2ccc(Oc3ccnc(c3)-c3cnn(C)c3)c(C)n2)C1=O

InChI Key InChIKey=ZVDXPHOUNMAVMQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 181037   

TargetMacrophage colony-stimulating factor 1 receptor [538-972](Human)
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM181037(US9133183, Example 42)
Affinity DataIC50: 8nMpH: 7.5 T: 2°CAssay Description:Activity of unphosphorylated c-FMS kinase (uFMS, Seq. ID no. 1) was determined by following the production of ADP from the FMS kinase reaction with A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2016
Entry Details
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TargetHepatocyte growth factor receptor(Human)
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM181037(US9133183, Example 42)
Affinity DataIC50: 5.00E+3nMT: 2°CAssay Description:These tests measure the ability of compounds to inhibit the enzymatic activity of recombinant human c-Met/HGF receptor and VEGF receptor enzymatic ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2016
Entry Details
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TargetVascular endothelial growth factor receptor 2(Human)
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM181037(US9133183, Example 42)
Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:These tests measure the ability of compounds to inhibit the enzymatic activity of recombinant human c-Met/HGF receptor and VEGF receptor enzymatic ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2016
Entry Details
Go to US Patent