BDBM181024 US9676721, 80 2-cyano-1-{[4-(1-methyl-1H-indole-2-sulfonyl)phenyl]methyl}-3-(pyridin-4-yl)guanidine

SMILES Cn1c(cc2ccccc12)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1

InChI Key InChIKey=KOBJJSVCUUILJG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 181024   

TargetNicotinamide phosphoribosyltransferase(Human)
Forma Tm

US Patent
LigandPNGBDBM181024(US9676721, 80 2-cyano-1-{[4-(1-methyl-1H-indole-2-...)
Affinity DataIC50: 2.10nMpH: 7.5 T: 2°CAssay Description:The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
Go to US Patent