BDBM181023 US9133183, Compound A

SMILES Cn1cc(cn1)-c1cc(Oc2ccc(NC(=O)N3CCN(C3=O)c3ccc(F)cc3)nc2)ccn1

InChI Key InChIKey=ADLRDDWBCKMWCY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 181023   

TargetMacrophage colony-stimulating factor 1 receptor [538-972](Human)
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM181023(US9133183, Compound A)
Affinity DataIC50: 13nMpH: 7.5 T: 2°CAssay Description:Activity of unphosphorylated c-FMS kinase (uFMS, Seq. ID no. 1) was determined by following the production of ADP from the FMS kinase reaction with A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2016
Entry Details
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TargetHepatocyte growth factor receptor(Human)
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM181023(US9133183, Compound A)
Affinity DataIC50: 196nMT: 2°CAssay Description:These tests measure the ability of compounds to inhibit the enzymatic activity of recombinant human c-Met/HGF receptor and VEGF receptor enzymatic ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2016
Entry Details
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TargetVascular endothelial growth factor receptor 2(Human)
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM181023(US9133183, Compound A)
Affinity DataIC50: 990nMT: 2°CAssay Description:These tests measure the ability of compounds to inhibit the enzymatic activity of recombinant human c-Met/HGF receptor and VEGF receptor enzymatic ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2016
Entry Details
Go to US Patent